Frank’s sign is a diagonal crease in the lobule of the auricle

“The sensitivity of Frank’s sign reaches 75%, its specificity 57.5% and its positive predicting value 80.3%. The prevalence of Frank’s sign increases progressively with age: 42% in the 30-39 age group and 75.8% in the 60-69 age group.

Frank’s sign is considered as a marker of the coronary disease, independent of risk factors but frequently associated with them. If its absence does not permit in any way to exclude the diagnosis of coronary disease, its presence corresponds in three quarters of the cases to an established coronary disease within a symptomatic population.”

Extracted from Darren’s blog

Frank’s sign is a diagonal crease in the lobule of the auricle :

Grade 3 – a deep cleft across the whole earlobe
Grade 2a – crease more than halfway across the lobe
Grade 2b – crease across the lobe, but superficial
Grade 1 – lesser degree of wrinkling